Evaluation of neurological events following minimally invasive mitral valve surgery

Tran Viet Chuong Pham, Duc Thang Ho1, , Quang Thuan Phan, Duc An Vinh Bui, Hoang Dinh Nguyen
1 Khoa Phẫu thuật Tim mạch người lớn, Bệnh viện Đại học Y Dược Tp Hồ Chí Minh

Main Article Content

Abstract

Objective: To determine the rate of neurological events in patients undergoing minimally invasive mitral valve surgery and evaluate factors associated with the groups with and without postoperative neurological events.


Subjects and Methods:



  • Inclusion Criteria: Patients undergoing minimally invasive mitral valve surgery at the Cardiac Surgery Department, University Medical Center.

  • Exclusion Criteria: Patients with infective endocarditis, patients requiring ECMO support.

  • Study Design: Retrospective case series study.


Results: A total of 358 patients underwent minimally invasive mitral valve surgery between 2017 and 2022, with an average age of 50.7 years. Male patients accounted for 53.2%, and the surgical risk according to EuroScore II was 1.6%. Neurological complications occurred in 46 patients, representing 12.8%. Among these, delirium was the most common complication, occurring in 42 patients (91.3%), while stroke with sequelae occurred at a lower rate of 2.2%.


The average age of the group with neurological complications was higher than that of the group without complications (53.9 ± 10.8 years vs. 50.2 ± 12.6 years). Additionally, the male proportion in the complication group (63.0%) was higher than in the group without complications (50.6%). The history of stroke in the complication group was 4.3%. The duration of mechanical ventilation and ICU stay was longer in the group with neurological complications, with an average mechanical ventilation time of 36.1 ± 71.3 hours compared to 18.4 ± 24.5 hours in the group without complications. The rate of new-onset atrial fibrillation after surgery was also higher in the complication group (19.6% vs. 10.6%).


Conclusion: Neurological complications after surgery are a significant issue, occurring in 12.8% of patients undergoing minimally invasive mitral valve surgery, with delirium and stroke being the most common. Key risk factors include age, hypertension, and atrial fibrillation.

Article Details

References

[1] Ordóñez-Velasco, L.M. and E. Hernández-Leiva, Factors associated with delirium after cardiac surgery: A prospective cohort study. Ann Card Anaesth, 2021. 24(2): p. 183-189.
[2] Wei, S., et al., Cerebral infarction after cardiac surgery. Ibrain, 2022. 8(2): p. 190-198.
[3] Glauber, M., et al., Early and long-term outcomes of minimally invasive mitral valve surgery through right minithoracotomy: a 10-year experience in 1604 patients. Journal of Cardiothoracic Surgery, 2015. 10: p. 1-9.
[4] Nasreddine, Z.S., et al., The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. Journal of the American Geriatrics Society, 2005. 53(4): p. 695-699.
[5] Kidwell, C.S., et al., Comparison of MRI and CT for detection of acute intracerebral hemorrhage. Jama, 2004. 292(15): p. 1823-1830.
[6] Newman, M.F., et al., Longitudinal assessment of neurocognitive function after coronary-artery bypass surgery. New England Journal of Medicine, 2001. 344(6): p. 395-402.
[7] Grossi, E.A., et al., Minimally invasive mitral valve surgery: a 6-year experience with 714 patients. The Annals of thoracic surgery, 2002. 74(3): p. 660-664.
[8] Grossi, E.A., et al., Minimally invasive valve surgery with antegrade perfusion strategy is not associated with increased neurologic complications. The Annals of thoracic surgery, 2011. 92(4): p. 1346-1350.
[9] Murzi, M., et al., Antegrade and retrograde arterial perfusion strategy in minimally invasive mitral-valve surgery: a propensity score analysis on 1280 patients. European Journal of Cardio-Thoracic Surgery, 2013. 43(6): p. e167-e172.
[10] Baeza-Herrera, L.A., et al., Atrial fibrillation in cardiac surgery. Archivos de cardiología de México, 2019. 89(4): p. 348-359.
[11] Holzhey, D.M., et al., Learning minimally invasive mitral valve surgery: a cumulative sum sequential probability analysis of 3895 operations from a single high-volume center. Circulation, 2013. 128(5): p. 483-491.
[12] Berretta, P., et al., Risk-related clinical outcomes after minimally invasive mitral valve surgery: insights from the Mini-Mitral International Registry. European Journal of Cardio-Thoracic Surgery, 2023. 63(6): p. ezad090.
[13] Berger, M., et al., Neurocognitive function after cardiac surgery: from phenotypes to mechanisms. Anesthesiology, 2018. 129(4): p. 829-851.