Results of surgical treatment for chronic pulmonary aspergillosis at the National Lung Hospital 2023-2024

Thi Thanh Dua Pham1, , Quoc Tuan Nguyen1, Duy Duc Dang, Van Luong Dinh1, Huu Lu Pham2
1 National Lung Hospital
2 Viet Duc University Hospital

Main Article Content

Abstract

Introduction: Chronic pulmonary Aspergillosis (CPA) is a condition where Aspergillus infection invades and develops chronically, gradually destroying lung structures. Surgical intervention is indicated for most patients with localized fungal lesions and severe, persistent, life-threatening hemoptysis. This study aims to evaluate the outcomes of surgical treatment for chronic pulmonary Aspergillosis at the National Lung Hospital from 2023 to 2024. Methods: This was a retrospective, cross-sectional descriptive study. It included 124 patients diagnosed with chronic pulmonary Aspergillosis who underwent surgical treatment at the National Lung Hospital from January 2023 to June 2024. Data were analyzed using Stata software. Results: Among 124 patients with chronic pulmonary Aspergillosis, 115 cases received conventional surgery and 9 underwent emergency surgery. There were 72 male patients (58.1%) and 52 female patients (41.9%). The average age was 53±14 years. The primary clinical symptom was hemoptysis (75.8%). The most common co-morbid lung disease was pulmonary tuberculosis, affecting 59 patients (47.6%). Lobectomy was the most frequent indication for moderate to severe hemoptysis, accounting for 85.7% of cases. The median duration of drainage was 5-6 days, and the median hospital stay was 8-12 days. The complication rate was under 10%, and the success rate was 98.28%. Four severe cases requested discharge. Conclusion: Surgical treatment for chronic pulmonary Aspergillosis is considered to have acceptable complication rates and should be performed in in specialised centres with experienced surgeons to manage and treat chronic pulmonary Aspergillosis, helping patients achieve complete recovery and improved quality of life without symptoms.

Article Details

References

1. Aspergilloma: a series of 89 surgical cases. The Annals of Thoracic Surgery. Accessed September 21, 2023. https://www.annalsthoracicsurgery.org/article/S0003-4975(99)01334-X/fulltext.
2. Balasubbiah, N., Saeteng, S., Siwachat, S., et al. Outcomes of pulmonary resection in pulmonary aspergilloma: A retrospective cohort study in a single tertiary-care hospital in Northern Thailand. Asian Journal of Surgery, 2024.02.003. https://doi.org/10.1016/j.asjsur.
3. Babasati, G., Massetti, M., Chapelier, A., et al. Surgical treatment of pulmonary aspergilloma: current outcome. J Thorac Cardiovasc Sur 2000;119:906-12.
4. Bongomin, F., et al. Surgical management of chronic pulmonary aspergillosis in Africa: A systematic review of 891 cases. Mycoses. 2021;00:1–8. DOI: 10.1111/myc.13359.
5. Chen, Q.-K., Jiang, G.-N. Surgical treatment for pulmonary aspergilloma: a 35-year experience in the Chinese population. Interactive CardioVascular and Thoracic Surgery 15 (2012) 77–80.
6. Denning, D. W., et al. ERS and ESCMID guideline for the management of chronic pulmonary aspergillosis released. Eur Respir J 2016; 47: 45–68 | DOI: 10.1183/13993003.00583-2015. http://ow.ly/Tzlsu.
7. Hakan Keskin, Hülya Diro, Nurgül Bozkurt. Pulmonary aspergilloma management: 5 years of experience from a tertiary hospital. Kardiochirurgia i Torakochirurgia Polska 2022; 19 (4): 194-198.
8. Harmouchi, H., Lakranbi, M., Issoufou, I., et al. Pulmonary aspergilloma: surgical outcome of 79 patients in a Moroccan center. Asian Cardiovascular & Thoracic Annals 2019, Vol. 27(6) 476–480.
9. He, B., et al. Clinical profile and surgical outcome for different types of chronic pulmonary aspergillosis. Am J Transl Res 2019;11(6):3671-3679. www.ajtr.org /ISSN:1943-8141/AJTR0091153.
10. Kumar, A., Asaf, B. B., Puri, H. V., et al. Video-assisted thoracoscopic surgery for pulmonary aspergilloma. Lung India 2017;34:318-23.
11. Koray, A., Funda, İ., Ş., M. F. Surgical management of pulmonary aspergilloma: clinical experience with 77 cases. Turkish Journal of Medical Sciences (2015) 45: 431-437.
12. Mohapatra, B., Sivakumar, P., Bhattacharya, S., et al. Surgical treatment of pulmonary aspergillosis: A single center experience. Lung India 2016;33:9-13.
13. Shen, C. M., et al. Outcomes of surgery for different types of chronic pulmonary aspergillosis: results from a single-center, retrospective cohort study. BMC Pulmonary Medicine (2022) 22:40. https://doi.org/10.1186/s12890-022-01836-z.
14. Smith, N. L., Denning, D. W. Underlying conditions in chronic pulmonary aspergillosis including simple aspergilloma. Eur Respir J. 2011;37(4):865-872.