Article Sidebar

PDF
Issue: Vol. 57
Section: Research Article
DOI: 10.47972/vjcts.v57i.1891
Date Published: 29/10/2026
Views 4
Downloads 1
How to Cite
Tieu, C. Q., Vu, N. T., Nguyen, D. T., Nguyen, D. G., Le, V. H., Nguyen, Q. H., Nguyen, M. N., & Dang, V. K. (2026). Outcomes of video-assisted thoracoscopic lobectomy with lymph node dissection for early-stage non-small cell lung cancer at Hanoi Medical University Hospital. The Vietnam Journal of Cardiovascular and Thoracic Surgery, 57, 70-78. https://doi.org/10.47972/vjcts.v57i.1891

Outcomes of video-assisted thoracoscopic lobectomy with lymph node dissection for early-stage non-small cell lung cancer at Hanoi Medical University Hospital

Cong Quyet Tieu1, Ngoc Tu Vu2, , Duy Thang Nguyen, Duy Gia Nguyen, Van Hung Le, Quang Huy Nguyen, Minh Ngoc Nguyen, Van Khanh Dang
1 Viet Tiep Friendship Hospital
2 Hanoi Medical University Hospital

Main Article Content

Abstract

Background: Video-assisted thoracoscopic lobectomy with systematic lymph node dissection has become a standard surgical treatment for early-stage non-small cell lung cancer. This study aimed to describe the clinical, paraclinical and pathological staging characteristics and to evaluate the surgical outcomes of this technique.


Methods: A retrospective descriptive study was conducted on 80 patients who underwent thoracoscopic lobectomy with lymph node dissection at Hanoi Medical University Hospital from September 2021 to December 2024. Survival was analysed using the Kaplan-Meier method and the log-rank test.


Results: The mean age was 61.3 ± 8.6 years and 53.8% of patients were male. Non-mucinous adenocarcinoma accounted for 85.0%, invasive mucinous adenocarcinoma for 5.0% and squamous cell carcinoma for 5.0%. There were 1, 55, 10 and 14 patients in stages 0, I, II and IIIA. Early complications occurred in 35.0% of patients, mostly Clavien-Dindo grade I–II, with prolonged air leak being the most common (17.5%); 30-day mortality was 1.3%. The three-year overall survival and disease-free survival rates were 86.2% and 62.6%, respectively. High-grade adenocarcinoma had significantly lower disease-free survival than grade 1–2 tumours (34.1% versus 69.8%; p = 0.023).


Conclusions: Thoracoscopic lobectomy with lymph node dissection for early-stage non-small cell lung cancer is safe, with low rates of severe complications and mortality and favourable mid-term survival. The histologic grade is a notable prognostic factor for disease-free survival.

Keywords

non-small cell lung cancer, video-assisted thoracoscopic surgery, obectomy, lymph node dissection, histologic grade, survival.

Article Details

References

1. Bray F, Laversanne M, Sung H. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2024;74(3):229–63. https://doi.org/10.3322/caac.21834.
2. Postmus PE, Kerr KM, Oudkerk M. Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2017;28(suppl_4):iv1–21. https://doi.org/10.1093/annonc/mdx222.
3. Bendixen M, Jørgensen OD, Kronborg C. Postoperative pain and quality of life after lobectomy via video-assisted thoracoscopic surgery or anterolateral thoracotomy for early stage lung cancer: a randomised controlled trial. Lancet Oncol 2016;17(6):836–44. https://doi.org/10.1016/S1470-2045(16)00173-X.
4. Goldstraw P, Chansky K, Crowley J. The IASLC Lung Cancer Staging Project: Proposals for Revision of the TNM Stage Groupings in the Forthcoming (Eighth) Edition of the TNM Classification for Lung Cancer. J Thorac Oncol 2016;11(1):39–51. https://doi.org/10.1016/j.jtho.2015.09.009.
5. Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 2004;240(2):205–13. https://doi.org/10.1097/01.sla.0000133083.54934.ae.
6. Phạm Hữu Lư, Nguyễn Mạnh Hiệp. Cắt thùy phổi kèm nạo vét hạch điều trị ung thư phổi không tế bào nhỏ giai đoạn sớm bằng phẫu thuật nội soi lồng ngực một lỗ. Tạp chí Y học Việt Nam 2022;513(2):291–4. https://doi.org/10.51298/vmj.v513i2.2491.
7. Lê Hải Sơn, Trần Trọng Kiểm, Mai Văn Viện et al. Kết quả sớm phẫu thuật nội soi cắt thùy phổi và nạo vét hạch điều trị ung thư phổi không tế bào nhỏ giai đoạn I, II, IIIA. Tạp chí Y Dược lâm sàng 108 2022;17(1):94–101.
8. Phạm Hữu Lư, Lê Văn Thực. Rò khí kéo dài sau phẫu thuật nội soi lồng ngực cắt thùy phổi do ung thư phổi không tế bào nhỏ tại Bệnh viện Hữu nghị Việt Đức. Tạp chí Y học Việt Nam 2022;512(1):168–71. https://doi.org/10.51298/vmj.v512i1.2222.
9. Moreira AL, Ocampo PSS, Xia Y. A Grading System for Invasive Pulmonary Adenocarcinoma: A Proposal From the International Association for the Study of Lung Cancer Pathology Committee. J Thorac Oncol 2020;15(10):1599–610. https://doi.org/10.1016/j.jtho.2020.06.001.
10. Darling GE, Allen MS, Decker PA. Randomized trial of mediastinal lymph node sampling versus complete lymphadenectomy during pulmonary resection in the patient with N0 or N1 (less than hilar) non-small cell carcinoma: results of the American College of Surgery Oncology Group Z0030 Trial. J Thorac Cardiovasc Surg 2011;141(3):662–70. https://doi.org/10.1016/j.jtcvs.2010.11.008.
11. Trần Minh Bảo Luân, Vũ Trí Thanh. Các yếu tố tiên lượng thời gian sống còn sau phẫu thuật điều trị ung thư phổi không tế bào nhỏ. Tạp chí Phẫu thuật Tim mạch và Lồng ngực Việt Nam 2018;23:75–85. https://doi.org/10.47972/vjcts.v23i.387.
12. Higuchi M, Yaginuma H, Yonechi A et al. Long-term outcomes after video-assisted thoracic surgery (VATS) lobectomy versus lobectomy via open thoracotomy for clinical stage IA non-small cell lung cancer. J Cardiothorac Surg 2014;9:88. https://doi.org/10.1186/1749-8090-9-88.
13. Fabbri G, Femia F, Lampridis S et al. Long-term oncologic outcomes in robot-assisted and video-assisted lobectomies for non-small cell lung cancer. J Clin Med 2023;12(20):6609. https://doi.org/10.3390/jcm12206609.