Article Sidebar

PDF
Date Published: 30/08/2025
Abstract Views: 4
Views PDF: 1
DOI: 10.47972/vjcts.v52i.1493
Issue
Vol. 52
Section
Research Article
How to Cite
Vo, T. N. A., Nguyen, N. T., & Vu, T. T. H. (2025). Impact of frailty on the outcomes of isolated coronary artery bypass grafting surgery. The Vietnam Journal of Cardiovascular and Thoracic Surgery, 52, 72 - 81. https://doi.org/10.47972/vjcts.v52i.1493

Impact of frailty on the outcomes of isolated coronary artery bypass grafting surgery

Thi Ngoc Anh Vo1, , Ngoc Tam Nguyen2, Thi Thanh Huyen Vu2
1 Hanoi Heart Hospital
2 Hanoi Medical University

Main Article Content

Abstract

Objective: Evaluate the impact of frailty on the outcomes of isolated coronary artery bypass grafting (CABG) surgery.


Subjects and Methods: A prospective, cross-sectional descriptive study was conducted on 195 patients undergoing non –emergency elective isolated CABG from January 2023 to February 2024 at Hanoi Heart Hospital. Frailty was assessed using the Essential Frailty Toolset (EFT).


Results: The prevalence of frailty syndrome was 21.01%, and the prevalence of pre-frailty was 53.3%. Frail patients were older, had a higher proportion of females, more comorbidities, a higher incidence of renal insufficiency, and greater dependency in daily functional activities compared to the pre-frail and non-frail groups (p < 0.05). Intraoperatively frail patients had higher rates of stroke, acute kidney injury, premature ventricular contractions, new-onset atrial fibrillation, pneumonia, and sepsis compared to the other groups (p < 0.05). Frail patients also had longer durations of mechanical ventilation and ICU stay, as well as a higher perioperative mortality rate compared to the pre-frail and non-frail groups. Multivariate analysis showed that frailty increased the risk of postoperative pneumonia by 4.38 times and the risk of composite STS adverse events by 1.67 times (p < 0.05).


Conclusion: Frailty syndrome, as assessed by the Essential Frailty Toolset, is a useful tool for identifying patients at higher risk of adverse outcomes following CABG surgery.

Keywords

Frailty syndrome, Coronary artery bypass grafting, Pneumonia, Composite STS outcome

Article Details

References

1. Fried LP, Cohen AA, Xue QL, Walston J, Bandeen-Roche K, Varadhan R. The physical frailty syndrome as a transition from homeostatic symphony to cacophony. Nature aging. Jan 2021;1(1):36-46. doi:10.1038/s43587-020-00017-z
2. Thakare VS, Sontakke NG, Wasnik Praful Sr , Kanyal D. Recent Advances in Coronary Artery Bypass Grafting Techniques and Outcomes: A narrative review. cureus. Sep 2023;15(9):e45511. doi:10.7759/cureus.45511
3. Lee JA, Yanagawa B, An KR, Arora RC, Verma S, Friedrich JO. Frailty and pre-frailty in cardiac surgery: a systematic review and meta-analysis of 66,448 patients. Journal of cardiothoracic surgery. Jun 25 2021;16(1):184. doi:10.1186/s13019-021-01541-8
4. Peeler A, Moser C, Gleason KT, Davidson PM. Frailty as a Predictor of Postoperative Outcomes in Invasive Cardiac Surgery: A Systematic Review of Literature. The Journal of cardiovascular nursing. May-Jun 01 2022;37(3):231-247. doi:10.1097/jcn.0000000000000821
5. Richter D, Guasti L, Walker D, et al. Frailty in cardiology: definition, assessment and clinical implications for general cardiology. A consensus document of the Council for Cardiology Practice (CCP), Association for Acute Cardio Vascular Care (ACVC), Association of Cardiovascular Nursing and Allied Professions (ACNAP), European Association of Preventive Cardiology (EAPC), European Heart Rhythm Association (EHRA), Council on Valvular Heart Diseases (VHD), Council on Hypertension (CHT), Council of Cardio-Oncology (CCO), Working Group (WG) Aorta and Peripheral Vascular Diseases, WG e-Cardiology, WG Thrombosis, of the European Society of Cardiology, European Primary Care Cardiology Society (EPCCS). European journal of preventive cardiology. Feb 19 2022;29(1):216-227. doi:10.1093/eurjpc/zwaa167
6. Solomon J, Moss E, Morin JF, et al. The Essential Frailty Toolset in Older Adults Undergoing Coronary Artery Bypass Surgery. Journal of the American Heart Association. 2021;10(15):e020219. doi:10.1161/JAHA.120.020219
7. Dent E, Morley JE, Cruz-Jentoft AJ, et al. Physical Frailty: ICFSR International Clinical Practice Guidelines for Identification and Management. The journal of nutrition, health & aging. 2019;23(9):771-787. doi:10.1007/s12603-019-1273-z
8. Soliman FK, Volk L, Kenath R, et al. Abstract 16763: Frailty, as Measured by the Essential Frailty Toolset, is Associated With Higher Resource Utilization in Patients Undergoing Coronary Artery Bypass Grafting. Circulation. 2020;142(Suppl_3):A16763-A16763. doi:10.1161/circ.142.suppl_3.16763.