Left ventricular decompression in veno-arterial extracorporeal membrane oxygenation

Mai Huong Ha1, , Van Thuc Nguyen, Thi Ngoc Anh Vo, Van Hoang, Sinh Hien Nguyen1
1 Hanoi Heart Hospital

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Abstract

Objective: Our study investigates the frequency and determines the characteristics and outcomes of patients with venoarterial extracorporeal membrane oxygenation (VA-ECMO) support requiring left ventricular unloading at Ha Noi Heart hospital.


Methods: A cross-sectional descriptive study was conducted among 84 patients undergoing  VA- ECMO between December 2018 and December 2021 at Ha Noi Heart hospital. Signs of  left ventricular distension in VA-ECMO (Inadequate arterial blood pressure pulsatility, “smoke like” effect in left ventricular, reduced aortic valve opening/absent aortic valve closure, pulmonary edema, left ventricular distension) were studied before and at  24 hours, 48 hours and 72 hours after VA-ECMO support.


Results: Left ventricular distention requiring decompression occurs in 44,1% of patients supported with VA-ECMO 3.6% (left ventricular distension), inadequate arterial blood pressure pulsatility (77,4%),  “smoke like” effect in left ventricular  (53,6%), pulmonary edema 47 ,6%; reduced aortic valve opening/absent aortic valve closure in 35,7% of the cases. Left ventricular decompression may improve clinical outcomes from 48 hours onwards (p<0.05). There were no differences in age, left ventricular ejection fraction before VA-ECMO, ECRP rates, continuous renal replacement therapy rates, duration of mechanical ventilation, duration of ECMO, hospital length of stay and diagnosis of patients with and without left ventricular unloading (p>0.05). The proportion of patients using invasive left ventricular decompression who successful weaning from VA- ECMO was significantly higher than in the group without left ventricular unloading (94,5% versus 74,4%; p<0.05).The survival rate of patients using left ventricular unloading tended to be higher than that in the group without left ventricular decompression (72,9% vs 53,2%; p>0.05) ). Complications of invasive left ventricular decompression included 1 patient with occlusion of the junction requires removal of the left atrial drainage.


Conclusion: Left heart decompression may contribute to increasing the success rate of VA-ECMO weaning and may help to improve the survival rate of patients with VA ECMO.

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References

1. Ricarte Bratti JP, Cavayas YA, Noly PE, Serri K, Lamarche Y. Modalities of Left Ventricle Decompression during VA-ECMO Therapy. Membranes (Basel). 2021;11(3):209. doi:10.3390/membranes11030209.
2. Lorusso R, Shekar K, MacLaren G, et al. ELSO Interim Guidelines for Venoarterial Extracorporeal Membrane Oxygenation in Adult Cardiac Patients. ASAIO Journal. 2021;67(8):827. doi:10.1097/MAT.0000000000001510
3. Xie A, Forrest P, Loforte A. Left ventricular decompression in veno-arterial extracorporeal membrane oxygenation. Annals of Cardiothoracic Surgery. 2019;8(1):98-18. doi:10.21037/acs.2018.11.07
4. Bộ Y Tế (2017) Hướng dẫn quy trình kỹ thuật nội khoa chuyên ngành tim mạch. (Quyết định 3983/QĐ-BYT quy trình kỹ thuật nội khoa chuyên ngành tim mạch của Bộ trưởng Bộ Y tế), Hà Nội
5. Rajsic S, Breitkopf R, Bukumiric Z, Treml B. ECMO Support in Refractory Cardiogenic Shock: Risk Factors for Mortality. Journal of Clinical Medicine. 2022;11(22):6821. doi:10.3390/jcm11226821
6. Cheng R, Hachamovitch R, Kittleson M, et al. Complications of Extracorporeal Membrane Oxygenation for Treatment of Cardiogenic Shock and Cardiac Arrest: A Meta-Analysis of 1,866 Adult Patients. The Annals of Thoracic Surgery. 2014;97(2):610-616. doi:10.1016/j.athoracsur.2013.09.008
7. Truby LK, Takeda K, Mauro C, et al. Incidence and Implications of Left Ventricular Distention During Venoarterial Extracorporeal Membrane Oxygenation Support. ASAIO J. 2017;63(3):257-265. doi:10.1097/MAT.0000000000000553
8. Grandin EW, Nunez JI, Willar B, et al. Mechanical Left Ventricular Unloading in Patients Undergoing Venoarterial Extracorporeal Membrane Oxygenation. Journal of the American College of Cardiology. 2022;79(13):1239-1250. doi:10.1016/j.jacc.2022.01.032
9. Chen K, Hou J, Tang H, Hu S. Concurrent Implantation of Intra-Aortic Balloon Pump and Extracorporeal Membrane Oxygenation Improved Survival of Patients With Postcardiotomy Cardiogenic Shock. Artif Organs. 2019;43(2):142-149. doi:10.1111/aor.13317
10. Bréchot N, Demondion P, Santi F, et al. Intra-aortic balloon pump protects against hydrostatic pulmonary oedema during peripheral venoarterial-extracorporeal membrane oxygenation. Eur Heart J Acute Cardiovasc Care. 2018;7(1):62-69. doi:10.1177/2048872617711169
11. Abrams D, Combes A, Brodie D. Extracorporeal membrane oxygenation in cardiopulmonary disease in adults. J Am Coll Cardiol. 2014;63(25 Pt A):2769-2778. doi:10.1016/j.jacc.2014.03.046
12. Al-Fares AA, Randhawa VK, Englesakis M, et al. Optimal Strategy and Timing of Left Ventricular Venting During Veno-Arterial Extracorporeal Life Support for Adults in Cardiogenic Shock. Circulation: Heart Failure. 2019;12(11):e006486. doi:10.1161/CIRCHEARTFAILURE.119.006486
13. Delmas C, Vallee L, Bouisset F, et al. Use of Percutaneous Atrioseptotosmy for Left Heart Decompression During Veno‐Arterial Extracorporeal Membrane Oxygenation Support: An Observational Study. Journal of the American Heart Association. 2022;11(17):e024642. doi:10.1161/JAHA.121.024642
14. Kowalewski M, Malvindi PG, Zieliński K, et al. Left Ventricle Unloading with Veno-Arterial Extracorporeal Membrane Oxygenation for Cardiogenic Shock. Systematic Review and Meta-Analysis. Journal of Clinical Medicine. 2020;9(4):1039. doi:10.3390/jcm9041039.