Đánh giá hiệu quả điều trị kháng đông ở bệnh nhân sau thay van tim cơ học tại bệnh viện tim Tâm Đức

Abstract

ABSTRACT:
Background: Patients with mechanical heart valve prostheses need lifelong oral anticoagulation therapy to prevent thrombosis. However, oral
anticoagulation has a narrow therapeutic window and has been associated with many drug-drug, drug-food interactions and the importance of strict adherence.Therefore, the patient’s knowledge of this drug is so important for effectiveness of oral anticoagulation
Objectives: (1) To evaluate the effectiveness of oral anticoagulationin patients with mechanical heart valve replacement; (2)To evaluate patients' knowledge of oral anticoagulation and its relationship to
anticoagulation control. Methods:observational and analytical, crosssectional study in 200 patients with mechanical heart valve replacement at Tam Duc Heart hospital.
Result:Total of 200 patients was included in the study. Sixty-nine patients (35.5%) were males. The mean age was 53.1 ± 9.7 years. Mitral valve
replacement was the most common indication for surgery (47.5%).The mean cumulative weekly dose of warfarin was 26.54 ± 8.27 mg and of acenocoumarol was 11,71 ± 2,1 mg. Fifty-three percent patients (53%) achieved therapeutic INR, the bleeding complication rate was 14.5%. Of the 200 patients, 18% presented good knowledge, and there was a positive correlation between patients’ warfarin knowledge and the INR values that was within the target range.*
Conclusion: Patients' knowledge of oral anticoagulationwas generally poor.Health education must be given to patients to increase their knowledge
regarding risk and prevention of complications in outpatient department and ward settings